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高泽霞

发布时间:2017-07-13来源:

1D339 

 

 

 

 

职称教授

学位博士

政治面貌 中共党员

电话18986008310

邮箱 gaozx@mail.hzau.edu.cn

研究方向水产动物种质资源评估、基因组与育种、基因编辑等

 

 

 教育经历 

20059月至20106月在bwin体育 - bwin足球下载|1888bwin学习,获博士学位

20078月至20093月在美国俄亥俄州立大学南方研究中心学习,联合培养博士

20019月至20057月在bwin体育 - bwin足球下载|1888bwin学习,获学士学位

 主要职历 

20181月至今,bwin体育 - bwin足球下载|1888bwin,教授,博士生导师

20169月至20179月,美国加州大学戴维斯分校,访问学者

201511月至201512月,挪威Nofima研究所,访问学者

20131月至201712月,bwin体育 - bwin足球下载|1888bwin,副教授,硕士生导师

20107月至201212月,bwin体育 - bwin足球下载|1888bwin,讲师

 科研成果 

科研获奖情况:

1. 获得农业部审定国家新品种——团头鲂华海1新品种入选2019中国农业农村重大科技新成果——十大新产品

2. 成果基于组学的团头鲂种质资源开发及育种技术体系的构建与应用获得湖北省2019科技进步一等奖

3. 成果团头鲂种质资源开发及分子辅助育种技术体系的构建与实践获得农业农村部20182019 年度神农中华农业科技奖一等奖

 

主持的科研项目:

1. 国家大宗淡水鱼产业技术体系鲂种质资源鉴定与新种质创制岗位CARS-45-08),2021-2025年;

2. 国家自然科学面上基金,基于转录组和代谢组学的团头鲂性早熟分子机制及其与生长发育之间的相互作用研究(项目编号:31872559),2019—2022

3. 国家重点研发计划蓝色粮仓科技创新重点专项,水产养殖生物性别发育与生产性状的关联机制(项目编号:2018YFD0900205),2018.122022.12

4. 湖北洪山实验室重大项目,主要养殖鱼类精准育种与产业化应用(2021hszd001)2021.11 -2024.12

5. 湖北省科技厅重点研发计划项目,鳡规模化繁育与驯养技术研究(2021BBA233),2021.12-2023.12.

6. 武汉市科技计划项目,有刺鱼和无刺鱼肌膈间充质干细胞分化机制研究(项目编号:2020020601012253),2020.8—2022.12

7. 国家自然科学面上基金,团头鲂let-7 microRNA对其生长和性腺发育的共同调控作用及其分子机制(项目编号:31472271),2015—2018

8. 国家自然科学青年基金,团头鲂HPG轴相关基因对其性早熟的分子调控机理研究(项目编号:31201988),2013—2015

9. 国家国际科技合作计划中克(克罗地亚)政府间科技合作项目,中国与克罗地亚有机水产养殖情况调查比较研究(项目编号:5-10),2011—2013

10. 国际香港保育基金,The Population Ecology and Genetic Diversity of the Endangered Tarim River System Endemic Fish Schizothorax biddulphi and its Implications for Conservation2011—2012

11. 教育部科技创新工作专项项目2021ZL08),长江流域重要鱼类种质资源库构建及优异种质创制,2021.12-2022.12

12. 湖北省杰出青年人才基金,2014—2016

13. 湖北省青年科技晨光计划B类,鱼类生长和性腺发育互作关键基因的功能及其基因调控网络研究(编号:9),2017—2018

14. 农业部农村部农业行业标准制定,制定《鳊》标准,2017

15. 教育部新教师基金,团头鲂KiSS-1/GPR54基因对其性早熟的分子调控作用研究(项目编号:20110146120021),2012—2014

16. 农业部财政部,湖北省水稻、园艺产业农技推广服务试点项目,湖北省稻渔综合种养提质增效技术集成与示范(项目编号:2011CDB138,子课题,20152017

17. 武汉市科技计划项目,鲌鲂远缘杂交快速育种技术体系的构建(项目编号:2019020702011375),2019.72021.12

18. 武汉市青年科技晨光计划,团头鲂肌间骨发生发育关键功能基因的挖掘与功能分析(项目编号:2016070204010143),2016—2018

19. 武汉市生态渔业产业技术体系-品种筛选岗位专家(项目编号:HBT-17180064-1803982018.01—2018.12

20. 横向课题,南美白对虾不同群体亲缘分析(项目编号:720107- 137144),2013—2014

21. 横向课题,海马SSR标记的开发与应用(项目编号:720107-137131),2013—2014

22. 横向课题,团头鲂微卫星家系鉴定方法技术许可使用,成果转化项目,2017.07—2037.06

 

发表的科研论文*通讯作者

1. Si-Qi Zhang, Xue-Mei Xiong, Rui-Hui Shi, Li-Fei Luo, Gui-Ying Wang, De-Wen Tang*, Qing Li*, Ze-Xia Gao*. Screening and characterization of sex-specific markers for the hybrid (Megalobrama amblycephala ♀ × Ancherythroculter nigrocauda ♂) based on 2b-RAD and transcriptome sequencing. Aquaculture, 2022, 548: 737704.

2. Xiao-Ru Dong, Shi-Ming Wan, Jia-Jia Zhou, Chun-Hong Nie, Yu-Long Chen, Jing-Han Diao, Ze-Xia Gao*. Functional differentiation of bmp7 genes in zebrafish: bmp7a for dorsal-ventral pattern and bmp7b for melanin synthesis and eye development. Front. Cell Dev. Biol. 10:838721.

3. Chunyan Li#, Melisa Olave#, Yali Hou#, Geng Qin#, Ralf F Schneider#, Zexia Gao#(共同第一), Xiaolong Tu, Xin Wang, Furong Qi, Alexander Nater, Andreas F. Kautt, Shiming Wan, Yanhong Zhang, Yali Liu, Huixian Zhang, Bo Zhang, Hao Zhang, Meng Qu, Shuaishuai Liu, Zeyu Chen, Jia Zhong, He Zhang, Lingfeng Meng, Kai Wang, Jianping Yin, Liangmin Huang, Byrappa Venkatesh‡, Axel Meyer*, Xuemei Lu*, Qiang Lin*. Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution. Nature Communications, 2021, 12:1094.

4. Han Liu, Chunhai Chen, Maolin Lv, Ning Liu, Yafei Hu, Hailin Zhang, Erik D. Enbody, Zexia Gao, Leif Andersson, and Weimin Wang. A chromosome-level assembly of blunt snout bream (Megalobrama amblycephala) genome reveals an expansion of olfactory receptor genes in freshwater fish. Molecular Biology and Evolution, 2021, 38 (10): 4238-4251.

5. Yulong Chen#, Shiming Wan#, Qing Li, Xiaoru Dong, Jinghan Diao, Qing Liao, Gui-Ying Wang, Ze-Xia Gao*. Genome-wide integrated analysis revealed functions of lncRNA-miRNA-mRNA interaction in growth of intermuscular bones in Megalobrama amblycephala. Frontiers in Cell and Developmental Biology, 2021, 8: 603815.

6. Chun-Hong Nie, Na-An Zhang, Yu-Long Chen, Zhen-Xia Chen, Gui-Ying Wang, Qing Li, Ze-Xia Gao*. A comparative genomic database of skeletogenesis genes: from fish to mammals. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2021, 38: 100796.

7. Chunhong Nie, Shiming Wan, Yulong Chen, Dejie Zhua, Xudong Wang, Xiaoru Dong, Ze-Xia Gao*. Loss of scleraxis leads to distinct reduction of mineralized intermuscular bone in zebrafish. Aquaculture and Fisheries, 2021, 6:169-177.

8. Lifang Liu, Yulong Chen, Jinghan Diao, Lifei Luo*, Zexia Gao*. Identification and characterization of novel circRNAs involved in muscle growth of blunt snout bream (Megalobrama amblycephala). Int. J. Mol. Sci. 2021, 22, 10056.

9. Li-Fei Luo, Zi-Sheng Xu, Eman Abdelwareth Baioumy Elsayed Elgazzar, Hang Du, Dan-Yang Li, Xiao-Yun Zhou*, Ze-Xia Gao*. Comparative transcriptome analysis revealed genes involved in sexual and polyploid growth dimorphisms in loach (Misgurnus anguillicaudatus). Biology, 2021, 10, 935.

10. Jia-Jia Zhou, Yong-Jie Chang, Yu-Long Chen, Xu-Dong Wang, Qing Liao, Rui-Hui Shi and Ze-Xia Gao. Comparison of Myosepta Development and Transcriptome Profiling between Blunt Snout Bream with and Tilapia without Intermuscular Bones. Biology, 2021, 10, 1311.

11. Jing Chen, Xiuli Chen, Xin Huang, Guanghua Huang, Zexia Gao, Weimin Wang, Han Liu*. Genome-wide analysis of intermuscular bone development reveals changes of key genes expression and signaling pathways in blunt snout bream (Megalobrama amblycephala). Genomics, 2021, 133(1): 654-663. 

12. Chun-Hong Nie, Alexandre Wagner Silva Hilsdorf, Shi-Ming Wan, Ze-Xia Gao*. Understanding the development of intermuscular bones in teleost: status and future directions for aquaculture. Reviews in Aquaculture, 2020, 12: 759–772. 

13. Shaokui Yi, Li-Fang Liu, Lai-Fang Zhou, Bo-Wen Zhao, Wei-Min Wang, Ze-Xia Gao*. Screening of biomarkers related to ovarian maturation and spawning in blunt snout bream (Megalobrama amblycephala) based on metabolomics and transcriptomics. Marine Biotechnology, 2020, 22:180-193.

14. J. R. S. Nunes, F. Pertille, S. C. S. Andrade§ , C. A. Perazza , P. M. S. Villela,V. M. F. Almeida-Val, Z.-X. Gao , L. L. Coutinho and A. W. S. Hilsdorf. Genome-wide association study reveals genes associated with the absence of intermuscular bones in tambaqui (Colossoma macropomum). Animal Genetics, 2020, 51, 899–909.

15. Chun-Hong Nie, Shi-Ming Wan, Yu-Long Liu, Han Liu, Wei-Min Wang, Ze-Xia Gao*. Development of teleost intermuscular bones undergoing intramembranous ossification based on histological-transcriptomic-proteomic data. International Journal of Molecular Sciences, 2019, 20, 4698. 

16. Shi-Ming Wan, Xue-Mei Xiong, Tea Tomljanovic, Yu-Long Chen, Han Liu, Tomislav Treer, Ze-Xia Gao*. Identification and mapping of SNPs associated with number of intermuscular bone in blunt snout bream. Aquaculture, 2019, 507, 75-82. 

17. Xue-Mei Xiong, Nicholas Andrew Robinson, Jia-Jia Zhou, Yu-Long Chen, Weimin Wang, Xu-Bo Wang, Ze-Xia Gao*. Genetic parameter estimates for intermuscular bone in blunt snout bream (Megalobrama amblycephala) based on a microsatellite-based pedigree. Aquaculture, 2019, 502: 371–377.

18. Tian Lan, Yu-Long Chen, Yasmeen Gul, Bo-Wen Zhao, Ze-Xia Gao*. Comparative expression analysis of let-7 microRNAs during ovary development in Megalobrama amblycephala. Fish Physiology and Biochemistry, 2019, 45: 1101-1105.

19. Ning-Nan Guan, Qiong Zhou*, Tian Lan, Lai-Fang Zhou, Bo-Wen Zhao, Wei-Min Wang, Ze-Xia Gao*. Is the nutritional value of fish fillet related to fish maturation or fish age? Integrated analysis of transcriptomics and metabolomics in blunt snout bream (Megalobrama amblycephala). Cellular Physiology and Biochemistry, 2018, 49:17-39.

20. Wei-Zhuo Zhang, Tian Lan, Chun-Hong Nie, Ning-Nan Guan, Ze-Xia Gao*. Characterization and spatiotemporal expression analysis of nine bone morphogenetic protein family genes during intermuscular bone development in blunt snout bream. Gene, 2018, 642: 116–124. (IF: 3.688)

21. Han Liu#, Chunhai Chen#, Ze-Xia Gao#, Jiumeng Min#, Yongming Gu#, Jianbo Jian#, Xiewu Jiang, Huimin Cai, Ingo Ebersberger, Meng Xu, Xinhui Zhang, Jianwei Chen, Wei Luo, Boxiang Chen, Junhui Chen, Hong Liu, Jiang Li, Ruifang Lai, Mingzhou Bai, Jin Wei, Shaokui Yi, Huanling Wang, Xiaojuan Cao, Xiaoyun Zhou, Yuhua Zhao, Kaijian Wei, Ruibin Yang, Bingnan Liu, Shancen Zhao, Xiaodong Fang, Manfred Schartl, Xueqiao Qian, Weimin Wang. The draft genome of blunt snout bream (Megalobrama amblycephala) reveals the development of intermuscular bone and adaptation to herbivorous diet. GigaScience, 2017, 6(7): 1-13.

22. Shi-Ming Wan, Hong Liu, Bo-Wen Zhao, Chun-Hong Nie, Wei-Min Wang, Ze-Xia Gao*. Construction of a high-density linkage map and fine mapping of QTL for growth and gonad related traits in blunt snout bream. Scientific Reports, 2017, 7: 46509.

23. Chun-Hong Nie, Shi-Ming Wan, Tea Tomljanovic, Tomislav Treer, Chung-Der Hsiao, Wei-Min Wang, Ze-Xia Gao*. Comparative proteomics analysis of teleost intermuscular bones and ribs provides insight into their development. BMC Genomics, 2017, 18:147. (IF: 3.969)

24. Lai-Fang Zhou, Bo-Wen Zhao, Ning-Nan Guan, Wei-Min Wang, Ze-Xia Gao*. Plasma metabolomics profiling for fish maturation in blunt snout bream. Metabolomics, 2017, 13(4): 40.

25. Bo-Wen Zhao, Lai-Fang Zhou, Yu-Long Liu, Shi-Ming Wan, Ze-Xia Gao*. Evolution of fish let-7 microRNAs and their expression correlated to growth development in blunt snout bream. International Journal of Molecular Sciences, 2017, 18(3): 646.

26. Wei Luo, Wei-Min Wang, Shi-Ming Wan, Qiang Lin, Ze-Xia Gao*. Assessment of parental contribution to fast- and slow-growth progenies in the blunt snout bream (Megalobrama amblycephala) based on parentage assignment. Aquaculture, 2017, 472: 23-29.

27. Xue-Mei Xiong, Yu-Long Chen, Li-Fang Liu, Weimin Wang, Nicholas Andrew Robinson*, Ze-Xia Gao*. Estimation of genetic parameters for resistance to Aeromonas hydrophila in blunt snout bream (Megalobrama amblycephala). Aquaculture, 2017, 479: 768-773.

28. 关柠楠, 聂春红, 陈宇龙, 刘莉芳, 高泽霞*. 团头鲂雌核发育群体的肌间骨形态学分析. 水产科学, 2017, 36(5): 596-600.

29. 陈宇龙, 张丽红, 周佳佳, 孟佑廉, 高泽霞*. 团头鲂肌腱发育相关基因tnmd/xirp2a的克隆和表达. 华中农业大学学报, 2019, 38(2): 1-8.

30. 聂春红,陈祖萱,戴彩娇,万世明,高泽霞*. 不同鱼类肌间骨的骨化模式研究. 水生生物学报,2018, 42(1): 131-137.

31. 关柠楠,兰天,陈宇龙,刘莉芳,周芬,高泽霞*. 团头鲂骨组织细胞系的建立及其生物学特性. 水产学报,2018, 42(4): 511-519.

32. 常永杰, 周佳佳, 张丽红, 孟佑廉, 高泽霞*. 刀鲚肌间骨新类型的发现. 水生生物学报, 2020, 44(1): 104-111.

33. 李丹阳,罗丽飞,曹文怡,周小云,高泽霞*. 雌激素受体基因对泥鳅雌雄和倍性生长差异的表达调控作用.华中农业大学学报,2020,39(6):164-172

34. 王旭东,唐雨甜,熊雪梅,周佳佳,李相珊,曹树洪,高泽霞*.团头鲂scxa基因SNP位点与肌间骨数目的关联性分析.华中农业大学学报,2021, 40(4): 149-156

35. 廖青, 万世明, 王旭东, 高泽霞*. 鱼类I型与II型胶原蛋白基因系统进化及其在有/无肌间骨代表鱼中的表达比较分析. 水生生物学报, 2021, 45(2): 318-326.

36. 王旭东, 聂春红, 高泽霞*. 鱼类肌间骨发育分子调控机制及遗传选育研究进展. 水生生物学报, 2021,  45(3): 680-691.

 

 

授权和申请专利:

1. 发明专利. 高泽霞万世明,聂春红,陈宇龙. 一段分离的核苷酸序列在肌间刺减少的斑马鱼构建中的应用. 授权专利号: ZL 2019 1 1104496.6. 授权日: 2021.5.7. 

2. 发明专利. 高泽霞聂春红,万世明,陈宇龙,朱德杰. 一段分离的核苷酸序列在无矿化肌间骨斑马鱼构建中的应用.授权专利号:2020 1 1115842.3. 授权日: 2021.9.24

3. 发明专利. 高泽霞, 万世明, 易少奎, 钟嘉, 王卫民. 一种团头鲂肌间骨总RNA提取方法. 授权专利号: ZL 2013 1 0673 534.6. 授权日: 2016.01.20.

4. 发明专利. 高泽霞, 王卫民, 曾聪, 罗伟, 王焕岭. 团头鲂微卫星家系鉴定方法. 授权专利号:ZL 2011 1 0051182.1. 授权日: 2013.10.23.

5. 发明专利. 高泽霞,王卫民,陈柏湘,刘肖莲,赵鸿昊,万世明,罗伟. 团头鲂生长性状相关的微卫星分子标记及应用. 授权专利号: ZL 2014 1 0654344.4. 授权日: 2017.10.10. 

6. 发明专利. 高泽霞,聂春红,周琼,魏开建,万世明,王卫民. 一种团头鲂成鱼肌间骨染色的方法及应用. 授权专利号: ZL 2015 1 1003963.8. 授权日: 2018.4.10. 

7. 发明专利. 高泽霞, 张思齐, 熊雪梅, 祝东梅, 李清、王贵英. 鲌鲂杂交种先锋2号的性别特异分子标记及应用. 授权专利号: ZL 2021 1 0624804.9. 授权日:2022.02.01

8. 实用新型. 高泽霞,张克磊,宋学东. 一种虾稻共作中多级排水系统的简易优化装置. 授权专利号:ZL 2018 2 1781100.2. 授权日2019.7.9.

9. 发明专利. 曾聪, 王卫民, 高泽霞, 曹小娟, 罗伟. 一种快速高效构建团头鲂半同胞家系的方法. 授权专利号: ZL 2011 1 0028552.X. 授权日: 2013.11.27.

10. 发明专利. 罗伟, 王卫民, 高泽霞, 曾聪, 邓伟. 一种筛选团头鲂群体杂交优势组合的方法. 授权专利号:  ZL 2011 1 0378926.0. 授权日: 2013.6.5.

11. 发明专利. 王卫民, 李艳和, 高泽霞. 一种鱼鳞基因组DNA的提取方法及专用试剂盒. 授权专利号:  ZL 2011 1 0028579.9.

12. 发明专利. 万世明(指导研究生),高泽霞,罗伟,赵鸿昊,林强,张艳红,张辉贤. 一种用于鉴别两个海马种群的SSR分子标记方法. 授权专利号: ZL 2014 1 0056237.1. 授权日: 2015.6.3.

13. 实用新型专利. 罗伟, 王卫民, 高泽霞, 曾聪, 张新辉, 温久福. 一种循环可控温的鱼苗孵化装置. 授权专利号:ZL 2011 2 0480012.0. 授权日: 2012.8.22.

14. 发明专利. 高泽霞,关柠楠,兰天,陈宇龙. 一种团头鲂骨组织细胞培养的方法. 申请号:201710358473.2. 发文日: 2017.05.19.

 

参编教材和专著:

1. 高泽霞. 第二章鱼类引种与驯化和第八章鱼类性别控制育种. 赵金良等主编的《鱼类育种学》十三五农业部规划教材。农业出版社,2017.

2. 王卫民,高泽霞,刘红等. 团头鲂种质资源与育种. 北京:科学出版社,2018.

3. Weimin Wang, Ze-Xia Gao. Recent developments in bream culture: culture systems and genetic improvement. In: Aquaculture in China: Success Stories and Modern Trends (Gui JF, Tang QS, Li ZJ, eds.). Wiley Blackwell, 2018.

4. Ze-Xia Gao, Bruce W. Draper. 2018. Gene Knockout and Its Principle and Application in Sex Control of Fish Species. In: Sex Control in Aquaculture (Wang, H.P., Piferrer, F. & Chen, S.L., eds.). John Wiley & Sons, Hoboken, NJ., pp 117 - 136.

5. Han-Ping Wang, Zhi-Gang Shen, Ze-Xia Gao, et al. Sex Determination and Control in Centrarchidae. In: Sex Control in Aquaculture (Wang, H.P., Piferrer, F. & Chen, S.L., eds.). John Wiley & Sons, Hoboken, NJ., pp 359 - 384.

 

 

 

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